Publications

  • Fransman W., Buist H., Kuijpers E., Walser T., Meyer D., Zondervan-van den Beuken E., Westerhout J., Klein Entink R.H., Brouwer D.H. (2016). Comparative Human Health Impact Assessment of Engineered Nanomaterials in the Framework of Life Cycle Assessment, Risk Analysis, epub ahead of print, doi: 10.1111/risa.12703. 
  • Brouwer, D., Boessen, R., Van Duuren-Stuurman, B., Bart, D., Moehlman, C., Bekker, C., Fransman, W., Klein Entink, R. (2016). Evaluation of decision rules in a tiered assessment of inhalation exposure to nanomaterials, Annals of Occupational Hygiene, 60, 949-959.
  • Houben, G., Burney, P., Chan, C.H., Crevel, R., Dubois, A., Faludi, R., Klein Entink, R., Knulst, A., Taylor, S., Ronsmans, S. (2016). Prioritisation of allergenic foods with respect to public health relevance. Report from an ILSI Europe Food Allergy Task Force Expert Group, Food and Chemical Toxicology, 89, 8-18.
  • Tan, E., Boessen, R., Fishwick, D., Klein Entink, R., Meijster, T., Pronk, A., van Duuren-Stuurman, B., Warren, N. (2015). A microsimulation model for the development and progression of chronic obstructive pulmonary disease, Respiratory Medicine,  109, 1521 – 1531.
  • Klein Entink, R.H., Bekker, C., Fransman, W.F., Brouwer, D.H. (2014). Analysis of time series of particle size distributions in nano exposure assessment, Journal of Aerosol Science, accepted for publication. Download the R-package with methods and data: NanoPSDA_1.0
  • Klein Entink, R.H., Remmington, B.C., Blom, W.M., Rubingh, C.M., Kruizinga, A.G., Baumert, J.L., Taylor, S.L., Houben, G.F. (2014). Food allergy population thresholds: An evaluation of the number of oral food challenges and dosing schemes on the accuracy of threshold dose distribution modelling, Food and Chemical Toxicology, 70, 134 – 143. [link]
  • McNally, K., Warren, N., Fransman, W., Klein Entink, R., Schinkel, J.,  van Tongeren, M., Cherrie, J.W., Kromhout, H., Schneider, T., Tielemans, E. (2014). Advanced REACH Tool (ART): A Bayesian model for occupational exposure assessment, Ann. Occup. Hyg., [Epub ahead of print].
  • Schinkel, S., Fransman, W., McDonnel, P. E., Klein Entink, R., Tielemans, E., Kromhout, H. (2014). Reliability of the Advanced REACH Tool (ART), Ann. Occup. Hyg., 1–19, doi:10.1093/annhyg/met081. [link]
  • Fox, J.-P., Klein Entink, R. H. and Timmers, C. F. (2014). The Joint Multivariate Modeling of Multiple Mixed Response Sources: Relating Student Performances with Feedback Behavior, Multivariate Behavioral Research, 49, 1-13. DOI: 10.1080/00273171.2013.843441. 
  • Fox, J.-P., Klein Entink, R. H. and Avetisyan, M. (2014). Compensatory and non-compensatory multidimensional randomized item response models, British Journal of Mathematical and Statistical Psychology, 67, 133-152. DOI: 10.1111/bmsp.12012. Data, R code and supportive materials.
  • Buist, H., Aldenberg, T., Batke, M., Escher, S., Klein Entink, R., Kühne, R., … Kroese, D. (2013). The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity. Regulatory Toxicology and Pharmacology, 67, 170 – 181. doi:10.1016/j.yrtph.2013.01.002
  • R. H. Klein Entink, W. Fransman and D. H. Brouwer (2011). How to statistically analyze nano exposure measurement results: Using an ARIMA time series approach. Journal of Nanoparticle Research, 13, 6991 – 7004.
  • A. van den Hout, J.-P. Fox and R. H. Klein Entink (2011). Bayesian inference for an illness-death model for stroke with cognition as a latent time-dependent risk factor. Statistical Methods in Medical Research, Accepted for publication.
  • R. H. Klein Entink, J.-P. Fox and A. van den Hout (2011). A mixture model for the joint analysis of latent developmental trajectories and survival. Statistics in Medicine, 30,  2310–2325.
  • F. Goldhammer and R. H. Klein Entink (2011). Speed of reasoning and its relation to reasoning ability. Intelligence, 39, 108-119.
  • W. J. van der Linden, R. H. Klein Entink and J.-P. Fox (2010). IRT parameter estimation with response times as collateral information, Applied Psychological Measurement, 34, 327 – 347.
  • R. H. Klein Entink, J.-P. Fox and W. J. van der Linden (2009). A Box-Cox normal model for response times, British Journal of Mathematical and Statistical Psychology, 62, 621–640.
  • R. H. Klein Entink, J.-T. Kuhn, L. F. Hornke and J.-P. Fox (2009). Evaluating cognitive theory: A joint modeling approach using responses and response times, Psychological Methods, 14, 54 – 57.
  • R. H Klein Entink, J.-P. Fox and W. J. van der Linden (2009). A multivariate multilevel approach to the modeling of accuracy and speed of test takers, Psychometrika, 74, 21 – 48.
  • R. H Klein Entink, J.-P. Fox, B. H. L. Betlem and B. Roffel (2007). Hierarchical process modeling: describing wtihin-run and between-run variation,  Journal of Process Control, 17, 349 – 361.
  • R. H Klein Entink, J.-P. Fox and W. J. van der Linden (2007). Modeling of response times and patterns: With a package CIRT, Journal of Statistical Software, 20, issue 7. http://www.jstatsoft.org.

Other Publications

  • Kruizinga, A.G., Klein Entink, R.H., Blom, W.M., Houben, G.F., van Bilsen, J.H.M. (2013). The scaling of allergenic products for the hazard characterisation of new products. Toxicology Letters, 221, S124. Kruizinga Tox letters 2013
  • Folkertsma, S., Fabriek, B. O., van Mierlo, G., Tielen, F. J., Klein Entink, R.H, Reefman, E., & Krul, C. (2013). Better prediction of immunogenicity of biopharmaceuticals in humans, is it possible?. Toxicology Letters, 221, S133-S134.
  • Uijt de Haag, P.A.M., Bellamy, L.J., Burdorf, A., ter Burg, W., Eysink, P., Heederik, D.J.J., Klein Entink, R.H., Manuel, H.J., Papazoglou, I.A., Pronk,A., Tielemans, E., Timmerman, J. (2011). Occupational Health or Occupational Safety: which impact is larger?, RIVM Report 620860002/2011. RIVM, The Netherlands.
  • Klein Entink, R. H., Fox, J.-P. (2010). Reactietijden in de Examinering. Stator, september 2010, pp 4-8.
  • Klein Entink, R.H. (2009). Statistical Models for Responses and Response Times, unpublished doctoral thesis, University of Twente, The Netherlands. [link] (2010 Psychometric Society Dissertation Award, article)

Presentations

  • Klein Entink, R. H., Remington, B., Blom, W.M., Rubingh, C., Kruizinga, A., Baumert,  J.L., Taylor, S., Houben, G.F. (2014). Food allergy population thresholds: an evaluation of the dosing scheme and number of oral food challenges on the accuracy of threshold dose studies. Oral presentation at FAAM, Dublin, Oct 9-11.
  • Klein Entink, R. H., Kruizinga, A.G., Fabriek, B., Blom, W.M., Houben, G.F., Bilsen, J.H.M. (2014).Quantitative prediction of the allergenicity of new or modified proteins. Poster presented at FAAM, Dublin, Oct 9-11.
  • Kruizinga, A.G., Klein Entink, R.H., Fabriek, B., Blom, W.M., Houben, G.F., Bilsen van, J.H.M. (2014). Quantitative prediciton of the allergenicity of new or modified proteins. Poster presented at the EAACI congress 2014. June 9-11, Kopenhagen.
  • Kruizinga A.G, Klein Entink, R.H., Blom, W.M. , Houben, G.F., van Bilsen, J.H.M. (2014). Determination of the relative allergenicity of food products for quantitative hazard assessment. Poster presented at the Society of Toxicology’s 53rd Annual Meeting, March 24 -27, Phoenix (AZ), USA.
  • Klein Entink, R.H., Kruizinga, A.G., Blom, W.M., Houben, G.F., van Bilsen, J.H.M. Development of a scale for food allergenic products for hazard characterization of new proteins, invited talk at the MTO Colloquium of the University of Tilburg, The Netherlands: February 4, 2014.
  • Kruizinga A.G, Klein Entink, R.H., Blom, W.M. , Houben, G.F., van Bilsen, J.H.M. (2013). The scaling of allergenic products for the hazard characterization of new proteins. Poster presented at EUROTOX, Interlaken, Switzerland, September 1-4.
  • Klein Entink, R.H., Fabriek, B., van Mierlo, G., Tielen, F., Reefman, E. (2013). Informative priors for modeling immunogenic responses of biopharmaceuticals. Paper presented at the Joint Statistical Meetings, Montreal, Canada, August 3-8.
  • Tan, E., Warren, N., Fishwick, D., Meijster, T., Klein Entink, R.H., Pronk, A. (2013). A dynamic population-based model for the development of chronic obstructive pulmonary disease. Paper presented at EPICOH 2013, Utrecht, The Netherlands, June 18-21.
  • Klein Entink, R. H., Meijster, T., Pronk, A., Tan, E., Warren, N., Heederik, D. (2013). A dynamic population-based model for the development of work-related respiratory health effects among motor vehicle repair workers exposed to isocyanates. Paper presented at EPICOH 2013, Utrecht, The Netherlands, June 18-21.
  • van Mierlo, G.M.,  Tielen, F. J., Klein Entink, R.H., Penninks, A., Sauerborn, M., Folkertsma, S., Reefman, E., Fabriek, B. (2013). Better Prediction of Immunogenicity of Biopharmaceuticals, Is It Possible? Poster presented at the 52nd Annual Meeting the Society of Toxicology, San Antonio, Texas, USA, March 10-14.
  • Pronk, A, Klein Entink, R. H., Heederik, D., Tielemans, E., Meijster,T.,  (2012). Developing a probabilistic exposure model for health impact assessment of interventions on isocyanate exposure. Paper presented at the 7th International Conference on the Science of Exposure Assessment, Edinburgh, UK.
  • Klein Entink, R.H.,Pronk, A, Meijster,T., Heederik, D., Tielemans, E. (2012). Impact of uncertainty in exposure data to silica in a health impact assessment among Dutch builders. Paper presented at the 7th International Conference on the Science of Exposure Assessment, Edinburgh, UK.
  • Schinkel, J., Klein Entink, R.H., McNally, K., Warren, N., van Tongeren, M., Cherrie, J.W., Fransman, W., Kromhout, H., Tielemans, E. (2012). How accurate are exposure assessment methods for REACH? Paper presented at the 7th International Conference on the Science of Exposure Assessment, Edinburgh, UK.
  • Klein Entink, R.H., Fox, J.P., van den Hout, A. (2011). A mixture model for latent developmental trajectories and survival. Paper presented at the Biostatistics Seminar, Erasmus MC, Rotterdam, December 2011.
  • Fransman, F., Klein Entink, R., Brouwer, D. (2011). Analysis of nano exposure measurement results. Paper presented at the 5th International Symposium on Nanotechnology, Occupational and Environmental Health , Boston, USA.
  • Klein Entink, R.H. Fox, J.-P., van den Hout, A. A mixture model for latent developmental trajectories and survival. Paper presented at the Joint Statistical Meetings 2011, Miami, Florida, USA.
  • Klein Entink, R.H. Statistical models for responses and response times (July 2010). Invited lecture, IMPS 2010, Athens, Georgia, USA,
  • Klein Entink, R.H. Fox, J.-P., van den Hout, A. A mixture model for latent developmental trajectories and survival. Paper presented at the IMPS 2010, Athens, Georgia, U.S.A.
  • Klein Entink, R. H. , Kuhn, J.-T., Hornke, L. F. & Fox, J.-P. (2009, July), Joint modeling of responses and response times to evaluate cognitive theory about item solving behavior. Paper presented at the meeting of the National Council of Measurement in Education, San Diego, USA.
  • Klein Entink, R.H., Linden, W.J. van der & Fox, G.J.A. (2008, June). IRT parameter estimation with response times as collateral information. Paper presented at the International Meeting of the Psychometric Society, Durham, USA
  • R.H. Klein Entink, W.J. van der Linden, J.-P. Fox (2007, July). Using flexible Box-Cox transformations when modeling response times on test items. Paper presented at the International Meeting of the Psychometric Society, Tokyo, Japan.
  • R.H. Klein Entink, J.-P. Fox, W.J. van der Linden (2006, June). Simultaneous modeling of responses and response times. Paper presented at the International Meeting of the Psychometric Society, Montreal, CA.